Bi-directional relationships of arterial stiffness with hypertension and diabetes mellitus from the early pathophysiological stages: a 16-year prospective observational study

Abstract Background Hypertension and diabetes mellitus frequently coexist; however, it has not yet been clarified if the bidirectional longitudinal relationships between arterial stiffness hypertension are independent of those mellitus. Methods In this 16-year prospective observational study, 3960 middle-aged employees a Japanese company without hypertension/diabetes at study baseline underwent annual repeated measurements blood pressure, serum glycosylated hemoglobin A1c levels (HbA1c), brachial-ankle pulse wave velocity (baPWV). Results By end period, 664, 779, 154, 406 subjects developed hypertension, prehypertension, mellitus, prediabetes, respectively. Increased baPWV was associated with significant odds ratio (per 1 standard deviation increase) for new onset prehypertension/hypertension (2.45/3.28, P<0.01) or (2.49/2.76, coexisting prediabetes/diabetes but hypertension. Analyses using latent growth curve model confirmed no such relationship observed abnormal glucose metabolism. Moreover, after adjustments, higher mean pressure accelerated increases in over follow-up (unstandardized coefficient [B] = 0.39, error [SE] 0.05x10–1, P<0.01). Similarly, (B 0.02x10–1, SE 0.01x10–1, (Figure 1). On other hands, HbA1c 0.43, P<0.01), did accelerate <0.01, P=0.52) 2). Conclusions company, contrast to that exist increased preceding development may represent as is only cases Therefore, be greater degree than Funding Acknowledgement Type funding sources: Private company. Main source(s): Omron Health Care Company (Kyoto, Japan),Teijin Pharma (Tokyo, Japan)